A section of the M62 motorway near Howden is currently closed due to a collison.
The Eastbound carriageway is currently closed between Junctions 37 and 38 following a police incident.
In a statement on social media, National Highways England said the road has been closed following a collision involving two vehicles, one of which has left the road.
It was later confirmed that it was a single vehicle accident.
Humberside Police, Humberside Fire and Rescue, Yorkshire Ambulance and Yorkshire Air Ambulance are said to be in attendance.
More details to follow.